OSE-279 is the key anti-PD-1 backbone component of OSE’s bifunctional checkpoint inhibitor BiCKI® platform that is targeting PD1 and other new immune targets. The first cytokine selected to be paired with the anti-PD1 in the bispecific antibody is Interleukin-7 (IL-7), which has been shown at preclinical stage to improve long-term immune functions and cancer immunotherapy efficacy. BiCKI®-IL-7 has potential to address the needs of a patient population in immune escape from checkpoint inhibitor treatment.
OSE-279 is being evaluated in a Phase 1/2 clinical trial in patients with advanced solid tumors or lymphomas. The first patient has been dosed in December 2022.
This first-in-human open label Phase 1/2 dose escalation and expansion study aims to determine the Maximum Tolerated Dose and/or the recommended Phase 2 dose of OSE-279 as a monotherapy in advanced solid tumors or lymphomas. Secondary objectives include assessment of OSE-279’s antitumor activity, evaluation of the safety profile, pharmacokinetic and receptor occupancy or pharmacodynamic profile.