Scientific publications

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2023 First-in-Human Study in Healthy Subjects with the Non-Cytotoxic 1 Monoclonal Antibody OSE-127, a Strict Antagonist of the IL-7Rα, Journal of Immunology, Feb. 2023
2022 “CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy”, Science Advances, Nov. 2022
2022 “Blockade of the myeloid CLEC-1 checkpoint enhances antitumor responses and tumor antigen cross-presentation”, SITC 2022
2022 “IL7R TME expression correlates with immunotherapy response and is associated with T-cell stemness with decreased apoptosis”, SITC 2022
2022 “Anti-PD-1/IL-7v bispecific antibody promotes TCF1+ stem like T-cells expansion and long-lasting in-vivo efficacy”, SITC 2022
2022 "Pattern of clinical activity of anticancer vaccine OSE2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO) in Phase 3 Atalante-1 randomized trial", ESMO 2022
2022 "Net Treatment Benefit of OSE2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO) in Phase 3 Atalante-1 randomized trial", ESMO 2022
2022 “Phase 2 clinical trial evaluating neo-epitope combination Tedopi® alone or in combination with Pembrolizumab versus best supportive care as maintenance treatment in platinum-sensitive recurrent ovarian cancer patients with disease control after platinum”, 2022 ASCO annual meeting
2022 “A Multicenter, Phase II, Open Label, Randomized Trial Evaluating Efficacy of Tedopi® Plus Docetaxel Or Tedopi Plus Nivolumab As Second-Line Therapy In Metastatic NSCLC Progressing After First-Line Chemo-Immunotherapy”, 2022 ASCO annual meeting
2022 “A randomized non-comparative phase II study of maintenance Tedopi® cancer vaccine alone or in combination with nivolumab, or FOLFIRI after induction with FOLFIRINOX in patients with advanced pancreatic ductal adenocarcinoma”, 2022 ASCO annual meeting
2022 “Quality of Life (QoL) of OSE2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO): Final data of Phase 3 Atalante-1 randomized trial”, 2022 ASCO annual meeting
2022 Biomarker analyses from the Phase I clinical trial of the first-in-class SIRPα immune checkpoint inhibitor BI 765063 in patients with advanced solid tumors : AACR 2022 (American Association Cancer Research)
2021 Combined exploratory immunophenotyping and transcriptomic tumor analysis in patients treated with OSE2101 (Tedopi®) vaccine in HLA-A2+ advanced non-small cell lung cancer (NSCLC) from the ATALANTE-1 trial: SITC (Society for Immunotherapy of Cancer) 2021
2021 Long-term anti-tumor preclinical efficacy of an optimized anti-PD-1/IL-7 bifunctional antibody sustaining activation of progenitor stem-like CD8 TILs and disarming Treg suppressive activity: SITC (Society for Immunotherapy of Cancer) 2021
2021 Phase I dose escalation study in patients (pts) with advanced solid tumours receiving first-in-class BI 765063, a selective signal-regulatory protein α (SIRPα) inhibitor, in combination with ezabenlimab (BI 754091), a programmed cell death protein 1 (PD-1) inhibitor: ESMO (European Society for Medical Oncology) 2021
2021 Preclinical efficacy of CLEC-1 antagonist as novel myeloid immune checkpoint therapy for oncology: SITC (Society for Immunotherapy of Cancer) 2021
2021 Activity of OSE-2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO): Final results of Phase 3 Atalante-1 randomised trial: ESMO 2021
2021 Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up: ESMO 2016
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