Pharma Partnerships

A key piece of OSE Immunotherapeutics’ business model

For OSE Immunotherapeutics, partnerships and out-licensing deals with global pharmaceutical companies represent ways to rapidly advance the clinical development of its product candidates. Selective partnerships represent a key piece of OSE’s business model that can contribute significantly to the cash flow needed to continue discovering and developing new targets and therapeutic candidates.

OSE Immunotherapeutics is actively pursuing a partnership strategy with potential pharmaceutical partners.

Existing partnerships signed with premier international pharmaceutical companies for the clinical development of the Company’s most advanced and innovative programs include the following:

  • AbbVie (February 2024) : A global licence and collaboration agreement to develop, manufacture and commercialize OSE-230 in chronic and severe inflammation.
  • Boehringer Ingelheim (April 2018): A global license and collaboration agreement to develop BI 765063 (OSE-172) in multiple cancer indications.
  • Veloxis Pharmaceuticals (April 2021): A global license agreement granting Veloxis worldwide rights to develop, manufacture and commercialize FR104 for all transplant indications (in parallel, OSE Immunotherapeutics retains all product rights to develop FR104 in autoimmune diseases).
  • Chong Kun Dang Pharmaceutical Corporation(CKD) (November 2019):  A licensing deal for potential registration and commercialization of Tedopi® in Korea.

 

Each of these agreements includes an initial upfront payment as well as milestone payments and royalties on potential future sales.

Together, existing partnerships represent a potential of up to €2.1 billion of revenue for OSE Immunotherapeutics and additional royalties on future sales, demonstrating our expertise discovering valuable new targets and therapies and validating the high potential of our drug candidates.

AbbVie / OSE-230

Upfront payment:

- 48 M$

A total of up to $713 million milestones + royalties on sales

BI 765063 / Boehringer Ingelheim

Milestones already received:

Already received:

- €65 M


A total of up to €1.1 billion milestones + royalties on sales

FR104 / VELOXIS

Milestones already received:

- €13.9 M

A total of up to €315 million + royalties on sales

Tedopi®/ CKD

Milestones already received:

- €1.2 M upfront upon signature and short-term milestone

A total up to €4.3 million milestones + royalties on sales and a margin within the transfer price

Up to €2.1 billion milestone payments + royalties on sales from partnerships; €180 million already received*.

*Including upfronts, milestones and reinvoiced R&D costs + previous license agreement and option of license with J&J and Servier + $48m upfront expected from AbbVie

MabSilico

OSE Immunotherapeutics collaborates with MabSilico, a deep technology innovative TechBio located in Tours, France, specialized in artificial intelligence algorithms to discover and characterize therapeutic antibodies, for several of its development programs.

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