Publications scientifiques

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2023 Blockade of the myeloid CLEC-1 checkpoint enhances antitumor responses and tumor antigen cross-presentation, American Association for Cancer Research (AACR) 2023

2023 TRIM21 is a novel endogenous partner of the inhibitory myeloid checkpoint CLEC-1 involved in tumor antigen cross-presentation, American Association for Cancer Research (AACR) 2023

2023 CD127 is expressed by acute lymphoblastic leukemias and is efficiently targeted by Lusvertikimab (OSE-127) through IL-7Rα blockade and antibody dependent phagocytosis, American Association for Cancer Research (AACR) 2023

2023 Anti-PD-1/IL-7v bispecific antibody (BICKI®IL7v) promotes TCF1+ stem like T cells expansion and long-lasting in vivo efficacy, American Association for Cancer Research (AACR) 2023

2023 Predictive response biomarkers from a Phase I clinical trial of a SIRPalpha inhibitor, BI 765063, stand-alone and in combination with ezabenlimab, a PD-1 inhibitor, in patients with advanced solid tumors, American Association for Cancer Research (AACR) 2023

2023 First-in-Human Study in Healthy Subjects with the Non-Cytotoxic 1 Monoclonal Antibody OSE-127, a Strict Antagonist of the IL-7Rα, Journal of Immunology, Feb. 2023

2022 "CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy", Science Advances, Nov. 2022

2022 “IL7R TME expression correlates with immunotherapy response and is associated with T-cell stemness with decreased apoptosis”, SITC 2022

2022 “Anti-PD-1/IL-7v bispecific antibody promotes TCF1+ stem like T-cells expansion and long-lasting in-vivo efficacy”, SITC 2022

2022 “Blockade of the myeloid CLEC-1 checkpoint enhances antitumor responses and tumor antigen cross-presentation”, SITC 2022

2022 "Pattern of clinical activity of anticancer vaccine OSE2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO) in Phase 3 Atalante-1 randomized trial", ESMO 2022

2022 "Net Treatment Benefit of OSE2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO) in Phase 3 Atalante-1 randomized trial", ESMO 2022

2022 “Quality of Life (QoL) of OSE2101 in HLA-A2+ non-small cell lung cancer (NSCLC) patients after failure to immune checkpoint inhibitors (IO): Final data of Phase 3 Atalante-1 randomized trial”, ASCO 2022

2022 “A randomized non-comparative phase II study of maintenance Tedopi® cancer vaccine alone or in combination with nivolumab, or FOLFIRI after induction with FOLFIRINOX in patients with advanced pancreatic ductal adenocarcinoma”, ASCO 2022

2022 “A Multicenter, Phase II, Open Label, Randomized Trial Evaluating Efficacy of Tedopi® Plus Docetaxel Or Tedopi Plus Nivolumab As Second-Line Therapy In Metastatic NSCLC Progressing After First-Line Chemo-Immunotherapy”, ASCO 2022

2022 “Phase 2 clinical trial evaluating neo-epitope combination Tedopi® alone or in combination with Pembrolizumab versus best supportive care as maintenance treatment in platinum-sensitive recurrent ovarian cancer patients with disease control after platinum”, ASCO 2022

2022 Biomarker analyses from the Phase I clinical trial of the first-in-class SIRPα immune checkpoint inhibitor BI 765063 in patients with advanced solid tumors : AACR 2022 (American Association Cancer Research)

2021 Phase I dose escalation study in patients (pts) with advanced solid tumours receiving first-in-class BI 765063, a selective signal-regulatory protein α (SIRPα) inhibitor, in combination with ezabenlimab (BI 754091), a programmed cell death protein 1 (PD-1) inhibitor: ESMO (European Society for Medical Oncology) 2021

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